Two Staging Systems for Chronic Lymphoid leukemia

TWO STAGING SYSTEMS FOR CCL

Rai staging system for chronic lymphoid leukemia

The Rai staging system is one of the two staging systems currently adopted in assessment of chronic lymphocytic leukemia(CLL).
It comprises of stages 0 to IV and classifies chronic lymphocytic leukemia into low, intermediate and high-risk categories, which correspond with stages 0, I & II, and III & IV, respectively:

• Rai stage 0:
• low risk 
• lymphocytosis: a high lymphocyte count defined as more than 15,000 lymphocytes per cubic millimeter (> 15,000/mm³)
• Rai stage I:
• intermediate risk 
• lymphocytosis + lymphadenopathy.
• Rai stage II:
• patients are also intermediate risk 
• lymphocytosis plus an enlarged liver (hepatomegaly) or enlarged spleen (splenomegaly), with or without lymphadenopathy
• Rai stage III:
• patients are high-risk 
• lymphocytosis plus anemia with or without lymphadenopathy, hepatomegaly, or splenomegaly
• Rai stage IV:
• high-risk 
• lymphocytosis + thrombocytopenia (< 100-103 /dL)

 

Binet staging system for chronic lymphocytic leukemia

The Binet staging system is one of the two staging systems currently adopted in assessment of chronic lymphocytic leukemia(CLL).
It classifies CLL according to the number of lymphoid tissues that are involved (i.e. the spleen and the lymph nodes of the neck, groin, and underarms), as well as the presence of anemia or thrombocytopenia

• stage A: 
• fewer than three areas of enlarged lymphoid tissue 
• no anemia
• no thrombocytopenia
• * lymphadenopathy in the neck, axillary, inguinal as well as the splenic involvement, are each considered as "one group," whether unilateral (one-sided) or bilateral (on both sides)
• stage B:
• three or more areas of enlarged lymphoid tissue 
• no anemia 
• no thrombocytopenia
• stage C:
• patients have anemia and/or thrombocytopenia regardless of lymphadenopathy